MicroRNA binding site polymorphisms as biomarkers in cancer management and research

@inproceedings{Cipollini2014MicroRNABS,
  title={MicroRNA binding site polymorphisms as biomarkers in cancer management and research},
  author={Monica Cipollini and Stefano Landi and Federica Gemignani},
  booktitle={Pharmacogenomics and personalized medicine},
  year={2014}
}
MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie several human diseases. Single nucleotide polymorphisms of transcripts may modulate the posttranscriptional regulation of gene expression by miRNAs and explain interindividual variability in cancer risk and in chemotherapy response. On the basis of recent association studies published in the… CONTINUE READING

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