MicroRNA-Restricted Transgene Expression in the Retina


BACKGROUND Gene transfer using adeno-associated viral (AAV) vectors has been successfully applied in the retina for the treatment of inherited retinal dystrophies. Recently, microRNAs have been exploited to fine-tune transgene expression improving therapeutic outcomes. Here we evaluated the ability of retinal-expressed microRNAs to restrict AAV-mediated… (More)
DOI: 10.1371/journal.pone.0022166


Cite this paper

@inproceedings{Karali2011MicroRNARestrictedTE, title={MicroRNA-Restricted Transgene Expression in the Retina}, author={Marianthi Karali and Anna Manfredi and Agostina Puppo and Elena Marrocco and Annagiusi Gargiulo and Mariacarmela Allocca and Michele della Corte and Settimio Rossi and Massimo Giunti and Maria Laura Bacci and Francesca Simonelli and Enrico Maria Surace and Alberto Auricchio}, booktitle={PloS one}, year={2011} }