MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation

@inproceedings{Bao2014MicroRNAPI,
  title={MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation},
  author={Yonghua Bao and Yongchen Guo and Zexin Li and Wenfeng Fang and Yiqiong Yang and Xuhan Li and Zhuangzhuang Li and Bowen Xiong and Zhiguo Chen and Jianguo Wang and Kang Kang and Deming Gou and Wancai Yang},
  booktitle={PloS one},
  year={2014}
}
Our previous studies have demonstrated that genetic deletion of the Muc2 gene causes colorectal cancers in mice. The current study further showed that at the early stage (<3 months) the Muc2 knockout mice spontaneously developed chronic inflammation in colon and rectum, similar pathological features as human colitis; and at the late stage (>3 months) the… CONTINUE READING