MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts

  title={MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts},
  author={Maryam Ghasemi-Kasman and Maryam Hajikaram and Hossein Baharvand and Mohammad Javan and Irina Kerkis},
  booktitle={PloS one},
BACKGROUND The conversion of astrocytes to neuroblasts holds great promise for treatment of neurodegenerative and traumatic brain diseases. METHODOLOGY AND PRINCIPAL FINDINGS Here we have shown that adult human astrocytes could be reprogrammed to neuroblasts by miR-302/367, both in vivo and in vitro. However, the reprogramming of adult mouse astrocytes to neuroblasts required valproic acid (VPA), a histone deacetylase inhibitor. Following induction of astrocytes toward neurons the expression… CONTINUE READING
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