MicroRNA-Mediated Control of Oligodendrocyte Differentiation

  title={MicroRNA-Mediated Control of Oligodendrocyte Differentiation},
  author={Xianghui Zhao and Xuelian He and Xiaolei Han and Yonghao Yu and Feng Ye and Yin Chen and Thaonguyen Hoang and Xiaomei Xu and Qing-Sheng Mi and Mei Qi Xin and Fan Wang and Bruce Appel and Qing Richard Lu},
MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive. To determine the role of miRNAs in the formation of myelinating oligodendrocytes, we selectively deleted a miRNA-processing enzyme, Dicer1, in oligodendrocyte lineage cells. Mice lacking Dicer1 display severe myelinating deficits despite an expansion of the oligodendrocyte progenitor pool. To search for miRNAs responsible for… CONTINUE READING
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