MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2

@inproceedings{Dong2010MicroRNALI,
  title={MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2},
  author={Qingchuan Dong and Ping Meng and Tao Wang and Weiwei Qin and Weijun Qin and Fuli Wang and Jianlin Yuan and Zhi-Nan Chen and An-gang Yang and He Wang},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Previous work has shown reduced expression levels of let-7 in lung tumors. But little is known about the expression or mechanisms of let-7a in prostate cancer. In this study, we used in vitro and in vivo approaches to investigate whether E2F2 and CCND2 are direct targets of let-7a, and if let-7a acts as a tumor suppressor in prostate cancer by down-regulating E2F2 and CCND2. METHODOLOGY/PRINCIPAL Findings Real-time RT-PCR demonstrated that decreased levels of let-7a are present in… CONTINUE READING

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