MicroRNA Genes and Their Target 3′-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers

Abstract

MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in… (More)
DOI: 10.1371/journal.pone.0035805

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Cite this paper

@inproceedings{Ryland2012MicroRNAGA, title={MicroRNA Genes and Their Target 3′-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers}, author={Georgina L. Ryland and Jennifer Bearfoot and Maria A. Doyle and Samantha E. Boyle and David Y. H. Choong and Simone M. Rowley and Richard W. Tothill and Kylie L. Gorringe and Ian G. Campbell}, booktitle={PloS one}, year={2012} }