MicroRNA-Gene Association As a Prognostic Biomarker in Cancer Exposes Disease Mechanisms

  title={MicroRNA-Gene Association As a Prognostic Biomarker in Cancer Exposes Disease Mechanisms},
  author={Rotem Ben-Hamo and S. Efroni},
  journal={PLoS Computational Biology},
  • Rotem Ben-Hamo, S. Efroni
  • Published 2013
  • Biology, Medicine, Computer Science
  • PLoS Computational Biology
  • The transcriptional networks that regulate gene expression and modifications to this network are at the core of the cancer phenotype. MicroRNAs, a well-studied species of small non-coding RNA molecules, have been shown to have a central role in regulating gene expression as part of this transcriptional network. Further, microRNA deregulation is associated with cancer development and with tumor progression. Glioblastoma Multiform (GBM) is the most common, aggressive and malignant primary tumor… CONTINUE READING
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