MicroRNA Expression in Zebrafish Embryonic Development

  title={MicroRNA Expression in Zebrafish Embryonic Development},
  author={E. Wienholds and W. Kloosterman and E. Miska and Ezequiel Alvarez-Saavedra and Eugene Berezikov and E. de Bruijn and H. Horvitz and S. Kauppinen and R. H. Plasterk},
  pages={310 - 311}
  • E. Wienholds, W. Kloosterman, +6 authors R. H. Plasterk
  • Published 2005
  • Biology, Medicine
  • Science
  • MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid–modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue… CONTINUE READING
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    References and Notes
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    13. Materials and methods are available as supporting material on Science Online
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