MicroRNA Expression in Zebrafish Embryonic Development

@article{Wienholds2005MicroRNAEI,
  title={MicroRNA Expression in Zebrafish Embryonic Development},
  author={E. Wienholds and W. Kloosterman and E. Miska and Ezequiel Alvarez-Saavedra and Eugene Berezikov and E. de Bruijn and H. Horvitz and S. Kauppinen and R. H. Plasterk},
  journal={Science},
  year={2005},
  volume={309},
  pages={310 - 311}
}
  • E. Wienholds, W. Kloosterman, +6 authors R. H. Plasterk
  • Published 2005
  • Biology, Medicine
  • Science
  • MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid–modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue… CONTINUE READING
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    • 14,384
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    • 497
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    • 492
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    • 1,074
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 25 REFERENCES
    MicroRNAs Regulate Brain Morphogenesis in Zebrafish
    • 1,208
    • PDF
    MicroRNA-Directed Cleavage of HOXB8 mRNA
    • 1,739
    • PDF
    References and Notes
    • 3,236
    • PDF
    13. Materials and methods are available as supporting material on Science Online
    • 1996