MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells

@inproceedings{Li2011MicroRNAEP,
  title={MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells},
  author={Shu-qiang Li and H F Moffett and Jun Lu and Lillian L Werner and Hao Zhang and Jerome Ritz and Donna S Neuberg and Kai W Wucherpfennig and Jennifer R Brown and Carl D. Novina},
  booktitle={PloS one},
  year={2011}
}
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recent data suggest that CLL cells may more closely resemble activated B cells. Using microRNA (miRNA) expression profiling of highly-enriched CLL cells from 38 patients and 9 untransformed B cells from normal donors before acute CpG activation and 5 matched B cells after acute CpG activation, we demonstrate an activated B cell status for CLL. Gene set enrichment analysis (GSEA) identified… CONTINUE READING

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