MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation

  title={MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation},
  author={Xiaorong Zhang and Xinxin Zuo and Bo Yang and Zongran Li and Yuanchao Xue and Yu Zhou and Jie Huang and Xiaolu Zhao and Jie Zhou and Yun Yan and Huiqiong Zhang and Peipei Guo and Hui Sun and Lin Guo and Yi Zhang and Xiang-Dong Fu},
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this… CONTINUE READING
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