MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

@inproceedings{Okoye2014MicroRNAContainingTE,
  title={MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells},
  author={Isobel S Okoye and Stephanie M. Coomes and Victoria S Pelly and Stephanie Czieso and Venizelos Papayannopoulos and Tanya Tolmachova and Miguel C. Seabra and Mark S Wilson},
  booktitle={Immunity},
  year={2014}
}
Foxp3(+) T regulatory (Treg) cells prevent inflammatory disease but the mechanistic basis of suppression is not understood completely. Gene silencing by RNA interference can act in a cell-autonomous and non-cell-autonomous manner, providing mechanisms of intercellular regulation. Here, we demonstrate that non-cell-autonomous gene silencing, mediated by miRNA-containing exosomes, is a mechanism employed by Treg cells to suppress T-cell-mediated disease. Treg cells transferred microRNAs (miRNA… CONTINUE READING
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