MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.

  title={MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.},
  author={Dorothee Hartmann and Jan Fiedler and Kristina Sonnenschein and Annette Just and Angelika Pfanne and Karina Zimmer and Janet Remke and Ariana Foinquinos and Malte Butzlaff and Katharina Schimmel and Lars Maegdefessel and Denise Hilfiker-Kleiner and Nico Lachmann and Andreas Schober and Natali Froese and Joerg Heineke and Johann Bauersachs and S{\'a}ndor B{\'a}tkai and Thomas Thum},
  volume={134 24},
BACKGROUND The transcription factor GATA2 orchestrates the expression of many endothelial-specific genes, illustrating its crucial importance for endothelial cell function. The capacity of this transcription factor in orchestrating endothelial-important microRNAs (miRNAs/miR) is unknown. METHODS Endothelial GATA2 was functionally analyzed in human endothelial cells in vitro. Endogenous short interfering RNA-mediated knockdown and lentiviral-based overexpression were applied to decipher the… CONTINUE READING
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