MicroRNA-Augmented Pathways (mirAP) and Their Applications to Pathway Analysis and Disease Subtyping

@article{Diaz2017MicroRNAAugmentedP,
  title={MicroRNA-Augmented Pathways (mirAP) and Their Applications to Pathway Analysis and Disease Subtyping},
  author={Diana Diaz and Michele Donato and Tin Nguyen and Sorin Draghici},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2017},
  volume={22},
  pages={
          390-401
        }
}
MicroRNAs play important roles in the development of many complex diseases. Because of their importance, the analysis of signaling pathways including miRNA interactions holds the potential for unveiling the mechanisms underlying such diseases. However, current signaling pathway databases are limited to interactions between genes and ignore miRNAs. Here, we use the information on miRNA targets to build a database of miRNA-augmented pathways (mirAP), and we show its application in the contexts of… CONTINUE READING