MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma.

@article{Martikainen2015MicroRNAAttenuatedCO,
  title={MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma.},
  author={Miika W. Martikainen and Minna Niittykoski and Mikael von und zu Fraunberg and A. S. T. Immonen and Susanna Koponen and Maartje van Geenen and Markus V{\"a}h{\"a}-Koskela and Erkko Yl{\"o}sm{\"a}ki and Juha E. J{\"a}{\"a}skel{\"a}inen and Kalle Saksela and A. E. Hinkkanen},
  journal={Journal of virology},
  year={2015},
  volume={89 20},
  pages={10637-47}
}
UNLABELLED Glioblastoma is a terminal disease with no effective treatment currently available. Among the new therapy candidates are oncolytic viruses capable of selectively replicating in cancer cells, causing tumor lysis and inducing adaptive immune responses against the tumor. However, tumor antiviral responses, primarily mediated by type I interferon (IFN-I), remain a key problem that severely restricts viral replication and oncolysis. We show here that the Semliki Forest virus (SFV) strain… CONTINUE READING
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