MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis

@article{Tao2018MicroRNA942MH,
  title={MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis},
  author={Le Quang Tao and Dongying Xue and Dongxiao Shen and Wenting Ma and Jie Zhang and Xuefei Wang and Wei Zhang and Liu Xue Wu and Kai Pan and Yanqin Yang and Zeribe Chike Nwosu and Steven Dooley and Ekihiro Seki and Cheng Liu},
  journal={Archives of Toxicology},
  year={2018},
  volume={92},
  pages={2935-2946}
}
MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in human liver fibrosis. The expression of miR-942, HSC activation markers, transforming growth factor-beta pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI), as well as collagen deposition, were investigated in 100 liver specimens from patients with varying degree of hepatitis B virus… CONTINUE READING
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