MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells.

  title={MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells.},
  author={Guillaume Dalmasso and Hang Nguyen and Yutao Yan and Hamed Laroui and Moiz A. Charania and Tracy Sitler Obertone and Shanthi V. Sitaraman and Didier Merlin},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={300 1},
MicroRNAs (miRNAs), which are noncoding RNAs that posttranscriptionally inhibit expression of target genes, have recently emerged as important regulators of many cellular functions such as cell differentiation. The epithelial di/tripeptide membrane transporter PepT1 is expressed in highly differentiated cells (the villous tip) but not in undifferentiated cells (the crypt) of the small intestine. Here, we investigated the regulation of PepT1 expression by miRNAs and its functional consequences… CONTINUE READING

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