MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.

@article{Tian2015MicroRNA9RT,
  title={MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.},
  author={Jie Tian and Ke Rui and Xinyi Tang and Jie Ma and Yungang Wang and Xinyu Tian and Yue Zhang and Huaxi Xu and Liwei Lu and Shengjun Wang},
  journal={Journal of immunology},
  year={2015},
  volume={195 3},
  pages={
          1301-11
        }
}
Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor-associated immunosuppression, thus affecting effective immunotherapies for cancers. However, the molecular mechanisms involved in regulating the differentiation and function of MDSCs remain largely unclear. In this study, we found that inhibition of microRNA (miR)-9 promoted the differentiation of MDSCs with significantly reduced immunosuppressive function whereas overexpression of miR-9 markedly enhanced the function of… CONTINUE READING

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