MicroRNA-9 Promotion of Interleukin-6 Expression by Inhibiting Monocyte Chemoattractant Protein-Induced Protein 1 Expression in Interleukin-1β-Stimulated Human Chondrocytes: MicroRNA-9 PROMOTION OF IL-6 EXPRESSION IN HUMAN CHONDROCYTES

@article{Makki2015MicroRNA9PO,
  title={MicroRNA-9 Promotion of Interleukin-6 Expression by Inhibiting Monocyte Chemoattractant Protein-Induced Protein 1 Expression in Interleukin-1β-Stimulated Human Chondrocytes: MicroRNA-9 PROMOTION OF IL-6 EXPRESSION IN HUMAN CHONDROCYTES},
  author={Mohammad Shahidul Makki and A. Haseeb and Tariq M Haqqi},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 8},
  pages={
          2117-28
        }
}
OBJECTIVE Enhanced expression of interleukin-6 (IL-6) plays an important role in the pathogenesis of osteoarthritis (OA). Monocyte chemoattractant protein-induced protein 1 (MCPIP-1) is a novel posttranscriptional regulator of IL-6 expression and is targeted by microRNA-9 (miR-9). We investigated the expression of MCPIP-1 in OA cartilage and explored whether targeting of MCPIP-1 by miR-9 contributes to enhanced IL-6 expression in OA. METHODS Gene and protein expression in IL-1β-stimulated… CONTINUE READING
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