MicroRNA-9 Modulates Cajal–Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium

@article{Shibata2008MicroRNA9MC,
  title={MicroRNA-9 Modulates Cajal–Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium},
  author={M. Shibata and D. Kurokawa and Hiromi Nakao and Tomomi Ohmura and S. Aizawa},
  journal={The Journal of Neuroscience},
  year={2008},
  volume={28},
  pages={10415 - 10421}
}
Vertebrate brain hosts a diverse collection of microRNAs, but little is known about their functions in vivo. Here we propose that mouse microRNA-9 (miR-9) targets Foxg1 mRNAs for proper generation of Cajal–Retzius cells in the medial pallium. miR-9 expression is mediolaterally graded, being most intense in the cortical hem; it contrasts with the Foxg1 expression in a reciprocal gradient. The 3′ untranslated regions of tetrapod, but not of teleost, Foxg1 mRNAs conserve miR-9 target sequences and… Expand
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