MicroRNA-765 influences arterial stiffness through modulating apelin expression.

  title={MicroRNA-765 influences arterial stiffness through modulating apelin expression.},
  author={Yi-Chu Liao and Yung-Song Wang and Edward Hsi and Ming-Hung Chang and Yun-Zhen You and S. H. Juo},
  journal={Molecular and cellular endocrinology},
The present study aims to discover single nucleotide polymorphisms (SNPs) at the apelin gene (APLN) in relation to arterial stiffness, and to explore its molecular mechanisms. A two-step genetic association study was conducted using 799 and 937 subjects in the screening and validation data, respectively. Four tagging SNPs of APLN were tested. SNP rs3115757 was significantly associated with stiffness parameters (β, Ep and PWV) in women, but not in men. The function of rs3115757 was tagged by… CONTINUE READING
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