MicroRNA-661 promotes non-small cell lung cancer progression by directly targeting RUNX3.

@article{Wang2017MicroRNA661PN,
  title={MicroRNA-661 promotes non-small cell lung cancer progression by directly targeting RUNX3.},
  author={Yu Wang and Yuqiang Li and Bin Wu and Ce Shi and Chen Li},
  journal={Molecular medicine reports},
  year={2017},
  volume={16 2},
  pages={
          2113-2120
        }
}
Lung cancer is the primary cause of cancer‑associated mortality in men and women worldwide. Increasing evidence indicates that abnormal microRNA (miRNA) expression contributes to the carcinogenesis and progression of multiple human cancers, including non‑small cell lung cancer (NSCLC). Therefore, miRNAs exhibit the potential to act as biomarkers for the diagnosis, treatment and prognosis of human malignancies. miRNA‑661 (miR‑661) has previously been demonstrated to be important in the… 

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References

SHOWING 1-10 OF 87 REFERENCES
miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression
TLDR
Investigation into the underlying mechanism of miR-19a revealed that MXD1 may be the key gene targeting miR -19a, participating in the process of proliferation and metastasis of lung cancer cells.
Role of microRNA-4458 in patients with non-small-cell lung cancer.
Incidence and progression of non-small-cell lung cancer (NSCLC) is a multi-factor, multi-step process. The present study investigated the association between the expression level of microRNA
MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.
miRNA signatures associate with pathogenesis and progression of osteosarcoma.
TLDR
A miRNA signature associated with pathogenesis of osteosarcoma as well as critical pre-treatment biomarkers of metastasis and responsiveness to therapy is established.
miR-143 inhibits bladder cancer cell proliferation and enhances their sensitivity to gemcitabine by repressing IGF-1R signaling.
TLDR
It is observed that miR-143 expression was downregulated in human bladder cancer tissues and cells, and that its levels were negatively correlated with bladder cancer clinical stages, and it is demonstrated that insulin-like growth factor-1 receptor (IGF-1R) is a functional target of mi R-143.
RUNX3 regulates renal cell carcinoma metastasis via targeting miR-6780a-5p/E-cadherin/EMT signaling axis.
TLDR
Runt-related transcription factor 3 targeted the miR-6780a-5p/E-cadherin/EMT signaling axis to suppress renal carcinoma cell migration and invasion and provides potential targets for the treatment of RUNX3 mutant and loss-of-function RCC tumors.
RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer.
TLDR
This work found that the reduction in expression of RUNX3 in CRC tissues when compared with tumor adjacent normal colon tissues, as indicated by reduced RUNx3 staining, was significantly correlated with tumor-node-metastasis (TNM) stage.
RUNX3 inhibits laryngeal squamous cell carcinoma malignancy under the regulation of miR‐148a‐3p/DNMT1 axis
TLDR
It is demonstrated that miR‐148a‐3p may regulate RUNX3 expression through the modulation of DNMT1‐dependent DNA methylation in LSCC, providing a novel target and a potential therapeutic pathway against LSCC.
Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer.
TLDR
Methylation of the RUNX3 gene promoter had a high relevance ratio in NSCLC tissue and correlated with clinical stage, lymph node metastasis and degree of differentiation; thus, this association may have clinical significance in NS CLC.
MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression
TLDR
It is demonstrated that miR-34c-3p functions as a tumor promoter by targeting NCKAP1 that is associated with prognosis in HCC and may be new potential molecular targets for HCC therapy.
...
...