MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice.

@article{Padi2013MicroRNA627MT,
  title={MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice.},
  author={Sathish K. R. Padi and Qunshu Zhang and Youcef M. Rustum and C India Morrison and B. F. Guo},
  journal={Gastroenterology},
  year={2013},
  volume={145 2},
  pages={437-46}
}
BACKGROUND & AIMS Vitamin D protects against colorectal cancer through unclear mechanisms. We investigated the effects of calcitriol (1α,25-dihydroxyvitamin D3; the active form of vitamin D) on levels of different microRNAs (miRNAs) in colorectal cancer cells from humans and xenograft tumors in mice. METHODS Expression of miRNAs in colorectal cancer cell lines was examined using the Ambion mirVana miRNA Bioarray. The effects of calcitriol on expression of miR-627 and cell proliferation were… CONTINUE READING
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