MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.

@article{Zheng2016MicroRNA511BT,
  title={MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.},
  author={Dali Zheng and Jonathan J. Sabbagh and Laura J Blair and April L. Darling and Xiaoqi Wen and Chad A Dickey},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 34},
  pages={17897-906}
}
Single nucleotide polymorphisms in the FKBP5 gene increase the expression of the FKBP51 protein and have been associated with increased risk for neuropsychiatric disorders such as major depression and post-traumatic stress disorder. Moreover, levels of FKBP51 are increased with aging and in Alzheimer disease, potentially contributing to disease pathogenesis. However, aside from its glucocorticoid responsiveness, little is known about what regulates FKBP5 In recent years, non-coding RNAs, and in… CONTINUE READING
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