MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.

  title={MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.},
  author={Yusuke Yamamoto and Nobuyoshi Kosaka and Minoru Tanaka and Fumiaki Koizumi and Yae Kanai and Takayuki Mizutani and Yoshiki Murakami and Masahiko Kuroda and Atsushi Miyajima and Takashi Kato and Takahiro Ochiya},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  volume={14 7},
We identified that microRNA expression changed dynamically during liver development and found that miR-500 is an oncofetal miRNA in liver cancer. miR-500 was abundantly expressed in several human liver cancer cell lines and 45% of human hepatocellular carcinoma (HCC) tissue. Most importantly, an increased amount of miR-500 was found in the sera of the HCC patients. In fact, miR-500 levels in sera of the HCC patients returned to normal after the surgical treatment in three HCC patients. Our… CONTINUE READING
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