MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.

@article{Wang2014MicroRNA497IO,
  title={MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.},
  author={Wei Wang and Fang Ren and Qinghua Wu and Dazhi Jiang and Hong-Jun Li and Zheng Peng and Jinglu Wang and Huirong Shi},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={449 4},
  pages={
          432-7
        }
}
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide. Understanding the molecular mechanism underlying ovarian cancer progression facilitates the development of promising strategy for ovarian cancer therapy. Previously, we observed frequent down-regulation of miR-497 expression in ovarian cancer tissues. In this study, we investigated the role of miR-497 in ovarian cancer metastasis. We found that endogenous miR-497 expression was down-regulated in the more… CONTINUE READING

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