MicroRNA-497 Inhibits Cardiac Hypertrophy by Targeting Sirt4

  title={MicroRNA-497 Inhibits Cardiac Hypertrophy by Targeting Sirt4},
  author={Y. Xiao and Xiaofei Zhang and Shihao Fan and Guanghao Cui and Zhenya Shen},
  booktitle={PloS one},
Cardiac hypertrophy is an adaptive enlargement of the myocardium in response to overload pressure of heart. From abundant studies, a conclusion is drawn that many microRNAs (miRNAs) are associated with cardiac hypertrophy and heart failure. To investigate the role of microRNA-497 (miR-497) in myocardial hypertrophy, two models were established in this study from cell level to integral level. Cardiac hypertrophy was induced by using angiotensin Ⅱ (Ang Ⅱ) in vitro and was created by transverse… CONTINUE READING