MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN.

@article{Liu2012MicroRNA494IR,
  title={MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN.},
  author={Yang Liu and Lihua Lai and Qingyun Chen and Yinjing Song and Sheng Xu and Feng Mei Ma and Xiaojian Wang and Jianli Wang and Hai Yu and Xuetao Cao and Qingqing Wang},
  journal={Journal of immunology},
  year={2012},
  volume={188 11},
  pages={5500-10}
}
Myeloid-derived suppressor cells (MDSCs) potently suppress the anti-tumor immune responses and also orchestrate the tumor microenvironment that favors tumor angiogenesis and metastasis. The molecular networks regulating the accumulation and functions of tumor-expanded MDSCs are largely unknown. In this study, we identified microRNA-494 (miR-494), whose expression was dramatically induced by tumor-derived factors, as an essential player in regulating the accumulation and activity of MDSCs by… CONTINUE READING
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