MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury.

  title={MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury.},
  author={Min Ki Jee and Jin Sun Jung and Jee I N Choi and Jin Jang and Kyung Sun Kang and Young Bin Im and Soo Kang},
  journal={Brain : a journal of neurology},
  volume={135 Pt 4},
MicroRNAs have been shown to effectively regulate gene expression at the translational level. Recently, we identified novel microRNAs that were upregulated in a mouse model of spinal cord injury. Among those, we have focused on microRNA 486, which directly represses NeuroD6 expression through a conserved sequence in its untranslated region. We correlated the overexpression of microRNA 486 in motor neurons with a poor outcome due to progressive neurodegeneration and a pathophysiology that is… CONTINUE READING
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