MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer.

@article{Hao2011MicroRNA4S,
  title={MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer.},
  author={Jun Hao and Shuyu Zhang and Yingqi Zhou and Xiangui Hu and Cheng-hao Shao},
  journal={FEBS letters},
  year={2011},
  volume={585 1},
  pages={207-13}
}
Both deregulation of tumor-suppressor genes and misexpression of microRNAs (miRNAs) have been implicated in the development of pancreatic cancer, but their relationship during this process remains less clear. Here, we report that the expression of miR-483-3p is strongly enhanced in pancreatic cancer tissues compared to side normal tissues using a miRNA-array differential analysis. Furthermore, DPC4/Smad4 is identified as a target of miR-483-3p and their expression levels are inversely… CONTINUE READING