MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson’s Disease

@article{Chen2017MicroRNA4639IA,
  title={MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson’s Disease},
  author={Yimeng Chen and Chao Gao and Qian Sun and Hong Pan and Pei Huang and Jianqing Ding and Shengdi Chen},
  journal={Frontiers in Aging Neuroscience},
  year={2017},
  volume={9}
}
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has profound impacts on the daily lives of patients. However, there is a lack of effective biomarkers for early diagnosis, and the mechanisms of PD pathogenesis remain obscure. microRNAs (miRNAs) are post-transcriptional gene regulators and can be easily detected in plasma, which suggests a promising role as diagnostic markers. Here, we aimed to explore a peripheral biomarker, which not only can be applied for… 

Figures and Tables from this paper

Circulating MicroRNAs and Long Non-coding RNAs as Potential Diagnostic Biomarkers for Parkinson’s Disease
TLDR
Recent advances in the detection of abnormally expressed miRNAs and lncRNAs in PD circulating fluids are reviewed and the determination of abnormalities in these biomarkers will be valuable for the future diagnosis and treatment of PD.
Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients
TLDR
BothmiR-132-3p and miR-146a-5p may function as promising biomarkers for early diagnosis of PD, as observed in serum samples of patients with PD and from severe PD patients.
Clinical Application of Circulating MicroRNAs in Parkinson's Disease: The Challenges and Opportunities as Diagnostic Biomarker
TLDR
The challenges in the application of microRNA in guiding disease discrimination decisions and its future prospects as a diagnostic biomarker in Parkinson's Disease are highlighted.
Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease
TLDR
The benefits of studying the role of non-coding RNAs in organ interactions when deciphering the complex regulatory networks involved in PD progression are discussed and the potential of systems biomedicine to derive and evaluate RNA biomarker signatures from high-throughput expression data is discussed.
Serum miR-214 Serves as a Biomarker for Prodromal Parkinson’s Disease
Circulating microRNAs (miRNAs) have been proposed to be accessible biomarkers for Parkinson’s disease (PD). However, there is a lack of known miRNAs that can serve as biomarkers for prodromal PD
Roles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson’s Disease
TLDR
A more thorough review of the current findings in the field of circulating non-coding RNAs in PD, highlighting their potential for being considered as biomarkers for diagnosis and holding promise for the use of peripheral biomarker for the diagnosis of PD.
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches
TLDR
An overview of the miRNAs recently found to be implicated in PD etiology is provided, with particular focus on their potential relevance as PD biomarkers, as well as their possible use in PD targeted therapy.
...
...

References

SHOWING 1-10 OF 49 REFERENCES
RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis
TLDR
The potential of miRNAs to serve a critical regulatory role in the implicated disease pathways, given their capacity to modulate the expression of entire families of related genes is highlighted.
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function.
TLDR
It is proposed that early deregulation of miR-34b/c in PD triggers downstream transcriptome alterations underlying mitochondrial dysfunction and oxidative stress, which ultimately compromise cell viability.
MicroRNAs as biomarkers for CNS disease
TLDR
The possibilities and challenges of using microRNA and other small RNAs as a signature for neurodegenerative and other neuropsychatric conditions are explored.
Differential DJ-1 gene expression in Parkinson's disease
MicroRNAs and neurodegeneration: role and impact.
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
TLDR
It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation
TLDR
It is demonstrated that DJ-1 functions as a redox-sensitive molecular chaperone that is activated in an oxidative cytoplasmic environment and extends to α-synuclein, a protein implicated in PD pathogenesis.
Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients
TLDR
It is discovered that the level of total DJ-1 protein is significantly reduced in the substantia nigra in brains of sporadic PD patients, and in the PD cortex mitochondria fraction, the HMWDJ-1 complex is significantly lower than in the NPC.
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
TLDR
A mechanism by which the DJ-1-dependent mitochondrial defects contribute to the increased sensitivity to oxidative stress-induced cell death that has been previously reported is defined.
...
...