MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway.

@article{Bao2012MicroRNA449AM,
  title={MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway.},
  author={J Bao and Ding Li and Li Wang and Jingwen Wu and Yanqin Hu and Zhugang Wang and Yan Chen and Xinkai Cao and Cizhong Jiang and Wei Yan and Chen Xu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 26},
  pages={21686-98}
}
MicroRNAs (miRNAs) mainly function as post-transcriptional regulators and are involved in a wide range of physiological and pathophysiological processes such as cell proliferation, differentiation, apoptosis, and tumorigenesis. Mouse testes express a large number of miRNAs. However, the physiological roles of these testicular miRNAs remain largely unknown. Using microarray and quantitative real time PCR assays, we identified that miRNAs of the microRNA-449 (miR-449) cluster were preferentially… CONTINUE READING
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