MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

@article{He2012MicroRNA375TA,
  title={MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo},
  author={X He and Y S Chang and F Meng and M Wang and Q Xie and Fangming Tang and P Li and Y Song and J Lin},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={3357-3369}
}
MicroRNAs (miRNAs) are believed to have fundamental roles in tumorigenesis and have great potential for the diagnosis and treatment of cancer. However, the roles of miRNAs in hepatocellular carcinogenesis are still not fully elucidated. We investigated the aberrantly expressed miRNAs involved in hepatoma by comparison of miRNA expression profiles in cancerous hepatocytes with normal primary human hepatocytes, and 37 dysregulated miRNAs were screened out by twofold change with a significant… CONTINUE READING
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