MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice.

@article{Nezami2014MicroRNA3M,
  title={MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice.},
  author={Behtash Ghazi Nezami and Simon Musyoka Mwangi and Jai Eun Lee and Sabrina Jeppsson and Mallappa Anitha and Shadi Sadeghi Yarandi and Alton Brad Farris and S. Deepak Srinivasan},
  journal={Gastroenterology},
  year={2014},
  volume={146 2},
  pages={473-83.e3}
}
BACKGROUND & AIMS A high-fat diet (HFD) can cause serious health problems, including alteration of gastrointestinal transit, the exact mechanism of which is not clear. Several microRNAs (miRNAs) are involved in energy homeostasis, lipid metabolism, and HFD-induced weight gain. We investigated the role of miRNAs in HFD-induced damage to the enteric nervous system. METHODS Male mice were fed a HFD (60% calories from fat) or regular diets (18% calories from fat) for 11 weeks. Mice on regular… CONTINUE READING