MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer.

@article{Basu2011MicroRNA375AM,
  title={MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer.},
  author={Aruna Basu and Hansjuerg Alder and Amer Khiyami and P. Michael Leahy and Carlo M. Croce and Subrata Haldar},
  journal={Genes & cancer},
  year={2011},
  volume={2 2},
  pages={108-19}
}
The deregulated presence or absence of microRNAs (miRNAs) might play an important role in molecular pathways leading to neoplastic transformation. At present, it is also thought that the approaches to interfere miRNA functions should be helpful for developing novel therapeutic opportunities for human cancer. In this study, we provide evidence that the anticancer agent benzyl isothiocyanate (BITC) has the ability to modulate the level of miRNAs such as miR-221 and miR-375, known to be abnormally… CONTINUE READING
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