MicroRNA-34a suppresses cell proliferation and induces apoptosis in U87 glioma stem cells.

@article{Sun2012MicroRNA34aSC,
  title={MicroRNA-34a suppresses cell proliferation and induces apoptosis in U87 glioma stem cells.},
  author={Lihua Sun and Zhifeng Wu and Yun Shao and Yi Pu and Weifeng Miu and Jianshe Yao and Yiping Wu and Zhengxiang Yang},
  journal={Technology in cancer research & treatment},
  year={2012},
  volume={11 5},
  pages={483-90}
}
Tumor stem cells (TSCs) have been identified in many malignant tumors and are unique in their self-renewal, multi-differentiation and tumor growth maintenance capabilities. MicroRNAs (miRNAs) are small endogenous, non-coding RNAs that predominately modulate target gene expression at the post-transcriptional level. Accumulating evidence suggests that some miRNAs have an essential role in TSC proliferation, growth, apoptosis, and differentiation. In particular, miR-34a has been found to inhibit… CONTINUE READING
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