MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1.

@article{Li2012MicroRNA34aMC,
  title={MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1.},
  author={Xiu-Juan Li and Ming-hua Ji and Shan-liang Zhong and Quan-bing Zha and Jin-jin Xu and Jian-Hua Zhao and Jin-Hai Tang},
  journal={Archives of medical research},
  year={2012},
  volume={43 7},
  pages={514-21}
}
BACKGROUND AND AIMS MicroRNA-34a (miR-34a) as a tumor suppressor has been reported in many other studies. However, its role in modulating the sensitivity of breast cancer cells to adriamycin (ADR) remains unclear. The aim of this study is to evaluate the role of miR-34a in the sensitivity of breast cancer cells to ADR. METHODS The role of miR-34a in breast cancer cells was detected using MTT assay, flow cytometry assay, real-time PCR and Western blot, etc. The association of miR-34a and… CONTINUE READING
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