MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction.

@article{Yang2015MicroRNA34aPA,
  title={MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction.},
  author={Yongkai Yang and Hui-Wen Cheng and Yiling Qiu and David Dupee and Madyson Noonan and Yi-Dong Lin and Sudeshna Fisch and Kazumasa Unno and Konstantina-Ioanna Sereti and Ronglih Liao},
  journal={Circulation research},
  year={2015},
  volume={117 5},
  pages={450-9}
}
RATIONALE In response to injury, the rodent heart is capable of virtually full regeneration via cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished as early as 1 week postnatal and remains lost in adulthood. The mechanisms that dictate postinjury cardiomyocyte proliferation early in life remain unclear. OBJECTIVE To delineate the role of miR-34a, a regulator of age-associated physiology, in regulating cardiac regeneration secondary to myocardial… CONTINUE READING
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