MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors.

@article{Badi2015MicroRNA34aIV,
  title={MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors.},
  author={Ileana Badi and Ilaria Burba and Clarissa Ruggeri and Filippo Zeni and Matteo Bertolotti and Alessandro Scopece and Giulio Pompilio and Angela Raucci},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2015},
  volume={70 11},
  pages={1304-11}
}
Arterial aging is a major risk factor for the occurrence of cardiovascular diseases. The aged artery is characterized by endothelial dysfunction and vascular smooth muscle cells altered physiology together with low-grade chronic inflammation. MicroRNA-34a (miR-34a) has been recently implicated in cardiac, endothelial, and endothelial progenitor cell senescence; however, its contribution to aging-associated vascular smooth muscle cells phenotype has not been explored so far. We found that miR… CONTINUE READING
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