MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).

@article{Goswami2015MicroRNA340mediatedDO,
  title={MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).},
  author={Srikanta Goswami and Rohinton S. Tarapore and Ashley M Poenitzsch Strong and Jessica J Teslaa and Yevgenya Grinblat and Vijayasaradhi Setaluri and Vladimir S. Spiegelman},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 1},
  pages={384-95}
}
Alternative cleavage and polyadenylation generates multiple transcript variants producing mRNA isoforms with different length 3'-UTRs. Alternative cleavage and polyadenylation enables differential post-transcriptional regulation via the availability of different cis-acting elements in 3'-UTRs. Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and melanogenesis. This central transcription factor is also implicated in melanoma development. Here… CONTINUE READING
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