MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1).

@article{Rice2013MicroRNA33aMT,
  title={MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1).},
  author={Shawn J. Rice and Shao-Chiang Lai and Lauren W Wood and Kaitlin R. Helsley and E Aaron Runkle and Monte M Winslow and David Mu},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 23},
  pages={16348-60}
}
In lung cancers, TTF-1 displays seemingly paradoxical activities. Although TTF-1 is amplified in primary human lung cancers, it inhibits primary lung tumors from metastasizing in a mouse model system. It was reported that the oncogenic proepithelial mesenchymal transition (EMT) high mobility group AT-hook 2 gene (HMGA2) mediates the antimetastatic function of TTF-1. To gain mechanistic insight into the metastasis-critical signaling axis of TTF-1 to HMGA2, we used both reverse and forward… CONTINUE READING
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