MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

@article{Ouimet2015MicroRNA33dependentRO,
  title={MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.},
  author={Mireille Ouimet and Hasini N. Ediriweera and Uma Mahesh Gundra and Frederick J. Sheedy and Bhama Ramkhelawon and Susan B. Hutchison and Kaitlyn Rinehold and Coen van Solingen and Morgan D Fullerton and Katharine Cecchini and Katey J Rayner and Gregory R Steinberg and Phillip D. Zamore and Edward A Fisher and P'ng Loke and Kathryn J Moore},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 12},
  pages={
          4334-48
        }
}
Cellular metabolism is increasingly recognized as a controller of immune cell fate and function. MicroRNA-33 (miR-33) regulates cellular lipid metabolism and represses genes involved in cholesterol efflux, HDL biogenesis, and fatty acid oxidation. Here, we determined that miR-33-mediated disruption of the balance of aerobic glycolysis and mitochondrial oxidative phosphorylation instructs macrophage inflammatory polarization and shapes innate and adaptive immune responses. Macrophage-specific… CONTINUE READING

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