MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin.

  title={MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin.},
  author={Jian-yong Sun and Yi Huang and Ji-peng Li and Xiang Zhang and Lei Wang and Yan-ling Meng and Bo Yan and Yong-Qian Bian and Jing Zhao and Wei Wang and An-gang Yang and Rui Zhang},
  journal={Biochemical and biophysical research communications},
  volume={420 4},
Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and underlying mechanisms in the development and progression of colorectal carcinoma has not been elucidated clearly. Here, we performed real-time PCR to examine the expression levels of miR-320a in colon cancer cell lines and tumor tissues. And then, we investigated its biological functions in colon cancer cells by a gain of… CONTINUE READING
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