MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma.

  title={MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma.},
  author={Wei Meng and Zhenqing Ye and Ri Cui and James M. Perry and Vaia Dedousi-Huebner and Alexander Huebner and Yao Wang and Bin Li and Stefano Volinia and Hiroshi Nakanishi and Taewan Kim and Sung-Suk Suh and Leona W. Ayers and Patrick Ross and Carlo M. Croce and Arnab Chakravarti and Victor X. Jin and Tim Lautenschlaeger},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 19},
PURPOSE We conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer tissue from patients of lung adenocarcinoma to identify markers for the presence of lymph node metastasis. EXPERIMENTAL DESIGN Markers for lymph node metastasis identified by sequencing were validated in a separate cohort using quantitative PCR. After additional validation in the The Cancer Genome Atlas (TCGA) dataset, functional characterization studies were conducted in vitro. RESULTS MiR-31 was upregulated in… CONTINUE READING
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Lung adenocarcinoma microRNA-31 expression levels to predict lymph node metastasis and patient survival

  • T Lautenschlaeger, W Meng, Z Ye, R Cui, J Perry, A Huebner
  • J Clin Oncol
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