MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

@inproceedings{Byrd2012MicroRNA30c2LE,
  title={MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response},
  author={Andrew E. Byrd and Ileana V. Aragon and Joseph W. Brewer},
  booktitle={The Journal of cell biology},
  year={2012}
}
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a multifaceted signaling system coordinating translational control and gene transcription to promote cellular adaptation and survival. Microribonucleic acids (RNAs; miRNAs), single-stranded RNAs that typically function as posttranscriptional modulators of gene activity, have been shown to inhibit translation of certain secretory pathway proteins during the UPR. However, it remains unclear whether miRNAs… CONTINUE READING

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