MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4

  title={MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4},
  author={Xiang Xia and Kundong Zhang and Gang Cen and Tao Jiang and Jun Cao and Kejian Huang and Chen Huang and Qian Zhao and Zhengjun Qiu},
BACKGROUND Aim to determine the clinicopathological and prognostic role of miR-301a-3p in pancreatic ductal adenocarcinoma(PDAC), to investigate the biological mechanism of miR-301a-3p in vitro and in vivo. METHODS By tissue microarray analysis, we studied miR-301a-3p expression in PDAC patients and its clinicopathological correlations as well as prognostic significance. qRT-PCR was used to test miR-301a-3p expression in PDAC tissues and cell lines. Functional experiments including in vitro… CONTINUE READING
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