MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma

@article{Rothschild2012MicroRNA29bII,
  title={MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma},
  author={Sacha I. Rothschild and Mario P Tschan and Elena A. Federzoni and Rolf Jaggi and Martin F. Fey and Mathias Gugger and Oliver Gautschi},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={4221-4232}
}
The c-Src kinase regulates cancer cell invasion through inhibitor of DNA binding/differentiation 1 (ID1). Src and ID1 are frequently overexpressed in human lung adenocarcinoma. The current study aimed at identifying microRNAs (miRNAs) involved in the Src-ID1 signaling in lung cancer. Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b, which was the most highly upregulated miRNA with predicted binding to the ID1 3… CONTINUE READING
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