MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

@article{Garzon2009MicroRNA29bIG,
  title={MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.},
  author={Ramiro Garzon and Shujun Liu and Muller Fabbri and Zhongfa Liu and Catherine E A Heaphy and Elisa Callegari and Sebastian Schwind and Jiuxia Pang and Jianhua Yu and Natarajan Muthusamy and Violaine Havelange and Stefano Volinia and William Blum and Laura J. Rush and Danilo Perrotti and Michael Andreeff and Clara D. Bloomfield and John C. Byrd and Kenneth K F Chan and Lai-Chu Wu and Carlo M. Croce and Guido Marcucci},
  journal={Blood},
  year={2009},
  volume={113 25},
  pages={6411-8}
}
Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression by targeting protein-coding mRNAs. Recently, miRNAs have been shown to play a role as both targets and effectors in gene hypermethylation and silencing in malignant cells. In the current study, we showed that enforced expression of miR-29b in acute myeloid leukemia cells resulted in marked… CONTINUE READING
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MicroRNA29b targets MCL-1 and is down-regulated in chemotherapy-resistant acute myeloid leukemia (AML) [abstract

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