MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption.

@article{Wang2013MicroRNA29aPA,
  title={MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption.},
  author={F Wang and Pei-Chin Chuang and Chung-Liang Lin and Mingwen Chen and Huei-Jin Ke and Yu-Hsuan Chang and Yu-Shan Chen and Shin-Long Wu and Jih-Yang Ko},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 6},
  pages={
          1530-40
        }
}
OBJECTIVE Excessive glucocorticoid treatment increases the incidence of osteopenia and osteonecrosis. MicroRNAs (miRNAs) reportedly target messenger RNA expression and regulate osteoblastogenesis and skeletal development. We undertook this study to investigate whether miR-29a regulates glucocorticoid-mediated bone loss. METHODS Rats were given methylprednisolone, lentivirus-mediated miR-29a precursor, or lentivirus-mediated miR-29a inhibitor. Dual x-ray absorptiometry, micro-computed… CONTINUE READING

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