MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

@article{Cai2019MicroRNA29EA,
  title={MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.},
  author={Jingjing Cai and He Xi Zhang and Yun-feng Zhang and Zhonglou Zhou and Shengzhou Wu},
  journal={Experimental cell research},
  year={2019},
  volume={374 1},
  pages={
          231-248
        }
}
Retinal pigment epithelial cells (RPEs), a pigmented cell layer in the outer retina, are constantly exposed to photo-oxidative stress. Autophagy relieves the stress by removing oxidative protein adducts, protein aggregates, and damaged mitochondria. We previously found that miR-29 is downregulated in choroid/RPE tissue in a model of exudative age-related macular degeneration (AMD), suggesting that miR-29 deficiency may contribute to autophagy inhibition and AMD progression. Here we wanted to… CONTINUE READING
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